CAS number

CAS 75-21-8 Ethylene oxide

CAS 75-21-8 · EC 200-849-9 · Index No 603-023-00-X

Where CAS 75-21-8 appears: every table entry that prints it among its identifiers, in the newest version of each act this record holds, and every recorded change to those entries. Many entries name a group of substances and print no number, so absence here is not absence from the law. Not legal advice.

Where it appears now

CLP Annex VI section 3, Index No 603-023-00-X

Last changed in the version in force 1 October 2021, by Regulation (EU) 2021/797 and 2 others, the acts that change names · Annex VI on this site

Annex VI section 3, table 1
Index No	Chemical name	EC No	CAS No	Classification		Labelling			Specific Conc. Limits, M-factors and ATEs	Notes
Index No	Chemical name	EC No	CAS No	Hazard Class and Category Code(s)	Hazard statement Code(s)	Pictogram, Signal Word Code(s)	Hazard statement Code(s)	Suppl. Hazard statement Code(s)	Specific Conc. Limits, M-factors and ATEs	Notes
603-023-00-X	ethylene oxide; oxirane	200-849-9	75-21-8	Flam. Gas 1 Press. Gas Carc. 1B Muta. 1B Repr. 1B Acute Tox. 3 Acute Tox. 3 STOT SE 3 STOT SE 3 STOT RE 1 Skin Corr. 1 Eye Dam. 1	H220 H350 H340 H360Fd H331 H301 H335 H336 H372 (nervous system) H314 H318	GHS02 GHS08 GHS06 GHS05 Dgr	H220 H350 H340 H360Fd H331 H301 H335 H336 H372 (nervous system) H314		inhalation: ATE = 700ppm (gases) oral: ATE = 100 mg/kg bw	U

CLP Annex VI section 3, table 2, Index No 603-023-00-X

Last changed in the version in force 1 December 2010, by Regulation (EC) No 790/2009, the act that change names · Annex VI on this site

Annex VI section 3, table 2
Index No	International Chemical Identification	EC No	CAS No	Classification	Labelling	Concentration Limits	Notes
603-023-00-X	ethylene oxide; oxirane	200-849-9	75-21-8	F+; R12 R6 Carc. Cat. 2; R45 Muta. Cat. 2; R46 T; R23 Xi; R36/37/38	F+; T R: 45-46-6-12-23-36/37/38 S: 53-45		E

Cosmetics Regulation Annex II, Reference number 182

No change to this entry since the first version the record holds, in force 11 July 2013. · Annex II on this site

Annex II, table 1
Reference number	Substance identification
Reference number	Chemical name/INN	CAS number	EC number
a	b	c	d
182	Ethylene oxide	75-21-8	200-849-9

PIC Regulation Annex I, the entry for Ethylene oxide (Oxirane)

Last changed in the version in force 1 July 2022, by Regulation (EU) 2022/643, the act that change names · Annex I on this site

Annex I, table 1
Chemical	CAS No	EC No	CN code	Subcategory	Use limitation	Countries for which no notification is required
Ethylene oxide (Oxirane)	75-21-8	200-849-9	ex29101000	p(1)	b	Please refer to PIC circular at www.pic.int/

PIC Regulation Annex I, table 3, the entry for Ethylene oxide

Last changed in the version in force 1 July 2022, by Regulation (EU) 2022/643, the act that change names · Annex I on this site

Annex I, table 3
Chemical	Relevant CAS number(s)	HS code Pure substance	HS code Mixtures containing substance	Category
Ethylene oxide	75-21-8	ex 2910.10	ex 3808.59 ex 3824.81	Pesticide

Plant Protection Products Regulation Annex III, No 41

Last changed in the version in force 27 March 2021, by Regulation (EU) 2019/1381 and Regulation (EU) 2021/383, the acts that change names · Annex III on this site

Annex III, table 1
No	Name	EC names/Other names	CAS number	EC number	Classification/Other properties
41.	Ethylene oxide	Ethylene oxide; Oxyrane; Epoxyethane	75-21-8	200-849-9	Carcinogenic cat.1B/ Mutagenic cat. 1B

REACH Annex XVII appendix 2, Index No 603-023-00-X

No change to this entry since the first version the record holds, in force 12 October 2008. · Annex XVII on this site

Annex XVII appendix 2, table 1
Substances	Index No	EC No	CAS No	Notes
Ethylene oxide; oxirane	603-023-00-X	200-849-9	75-21-8

REACH Annex XVII appendix 4, Index No 603-023-00-X

No change to this entry since the first version the record holds, in force 12 October 2008. · Annex XVII on this site

Annex XVII appendix 4, table 1
Substances	Index No	EC No	CAS No	Notes
Ethylene oxide; oxirane	603-023-00-X	200-849-9	75-21-8

REACH Annex XVII appendix 6, Index No 603-023-00-X

Last changed in the version in force 1 October 2021, by Regulation (EU) 2020/2096, the act that change names · Annex XVII on this site

Annex XVII appendix 6, table 1
Substances	Index No	EC No	CAS No	Notes
Ethylene oxide; oxirane	603-023-00-X	200-849-9	75-21-8

Look up a number

Type a CAS or EC number, with or without its hyphens, or an Index No into the search box at the top of the page: it reads 50000 as CAS 50-00-0. Every number is also listed by act on the substances page.

Its history

1 July 2022 · amended · PIC Regulation Annex I, the entry for Ethylene oxide (Oxirane)

Recorded in the version in force 1 July 2022, by Regulation (EU) 2022/643, the act that change names. The change on its version page

Amended entries, Annex I, table 1
Identifiers	Version	Chemical	CAS No	EC No	CN code	Subcategory	Use limitation	Countries for which no notification is required
Ethylene oxide (Oxirane)CAS 75-21-8EC 200-849-9	Before	Ethylene oxide (Oxirane)	75-21-8	200-849-9	~~29101000~~	p(1)	b	Please refer to PIC circular at www.pic.int/
Ethylene oxide (Oxirane)CAS 75-21-8EC 200-849-9	After	Ethylene oxide (Oxirane)	75-21-8	200-849-9	ex29101000	p(1)	b	Please refer to PIC circular at www.pic.int/

1 July 2022 · amended · PIC Regulation Annex I, table 3, the entry for Ethylene oxide

Recorded in the version in force 1 July 2022, by Regulation (EU) 2022/643, the act that change names. The change on its version page

Amended entries, Annex I, table 3
Identifiers	Version	Chemical	Relevant CAS number(s)	HS code Pure substance	HS code Mixtures containing substance	Category
Ethylene oxideCAS 75-21-8	Before	Ethylene oxide	75-21-8	2910.10	~~3808.50~~ 3824.81	Pesticide
Ethylene oxideCAS 75-21-8	After	Ethylene oxide	75-21-8	ex 2910.10	ex 3808.59 ex 3824.81	Pesticide

1 October 2021 · amended · CLP Annex VI section 3, Index No 603-023-00-X

Recorded in the version in force 1 October 2021, by Regulation (EU) 2021/797 and 2 others, the acts that change names. The change on its version page

Amended entries, Annex VI section 3, table 1
Identifiers	Version	Index No	Chemical name	EC No	CAS No	Classification		Labelling			Specific Conc. Limits, M-factors and ATEs	Notes
Identifiers	Version	Index No	Chemical name	EC No	CAS No	Hazard Class and Category Code(s)	Hazard statement Code(s)	Pictogram, Signal Word Code(s)	Hazard statement Code(s)	Suppl. Hazard statement Code(s)	Specific Conc. Limits, M-factors and ATEs	Notes
Index No 603-023-00-XCAS 75-21-8EC 200-849-9	Before	603-023-00-X	ethylene oxide; oxirane	200-849-9	75-21-8	~~Press. Gas~~ Flam. Gas 1 Carc. 1B Muta. 1B Acute Tox. 3 * Eye Irrit. 2 STOT SE 3 Skin ~~Irrit. 2~~	H220 H350 H340 H331 ~~H319~~ H335 ~~H315~~	GHS02 ~~GHS04~~ GHS06 ~~GHS08~~ Dgr	H220 H350 H340 H331 ~~H319~~ H335 ~~H315~~			U
Index No 603-023-00-XCAS 75-21-8EC 200-849-9	After	603-023-00-X	ethylene oxide; oxirane	200-849-9	75-21-8	Flam. Gas 1 Press. Gas Carc. 1B Muta. 1B Repr. 1B Acute Tox. 3 Acute Tox. 3 STOT SE 3 STOT SE 3 STOT RE 1 Skin Corr. 1 Eye Dam. 1	H220 H350 H340 H360Fd H331 H301 H335 H336 H372 (nervous system) H314 H318	GHS02 GHS08 GHS06 GHS05 Dgr	H220 H350 H340 H360Fd H331 H301 H335 H336 H372 (nervous system) H314		inhalation: ATE = 700ppm (gases) oral: ATE = 100 mg/kg bw	U

1 October 2021 · added · REACH Annex XVII appendix 6, Index No 603-023-00-X

Recorded in the version in force 1 October 2021, by Regulation (EU) 2020/2096, the act that change names. The change on its version page

Added entries, Annex XVII appendix 6, table 1
Identifiers	Substances	Index No	EC No	CAS No	Notes
Index No 603-023-00-XCAS 75-21-8EC 200-849-9	Ethylene oxide; oxirane	603-023-00-X	200-849-9	75-21-8

27 March 2021 · added · Plant Protection Products Regulation Annex III, No 41

Recorded in the version in force 27 March 2021, by Regulation (EU) 2019/1381 and Regulation (EU) 2021/383, the acts that change names. The change on its version page

Added entries, Annex III, table 1
Identifiers	No	Name	EC names/Other names	CAS number	EC number	Classification/Other properties
No 41CAS 75-21-8EC 200-849-9	41.	Ethylene oxide	Ethylene oxide; Oxyrane; Epoxyethane	75-21-8	200-849-9	Carcinogenic cat.1B/ Mutagenic cat. 1B

21 June 2013 · amended · CLP Annex VI section 3, Index No 603-023-00-X

Recorded in the version in force 21 June 2013, by Regulation (EU) No 487/2013 and 4 others, the acts that change names. The change on its version page

Amended entries, Annex VI section 3, table 1
Identifiers	Version	Index No	International Chemical Identification	EC No	CAS No	Classification		Labelling			Notes
Identifiers	Version	Index No	International Chemical Identification	EC No	CAS No	Hazard Class and Category Code(s)	Hazard statement Code(s)	Pictogram, Signal Word Code(s)	Hazard statement Code(s)	Suppl. Hazard statement Code(s)
Index No 603-023-00-XCAS 75-21-8EC 200-849-9	Before	603-023-00-X	ethylene oxide; oxirane	200-849-9	75-21-8	Press. Gas Flam. Gas 1 Carc. 1B Muta. 1B Acute Tox. 3 * Eye Irrit. 2 STOT SE 3 Skin Irrit. 2	H220 H350 H340 H331 H319 H335 H315	GHS02 GHS04 GHS06 GHS08 Dgr	H220 H350 H340 H331 H319 H335 H315
Index No 603-023-00-XCAS 75-21-8EC 200-849-9	After	603-023-00-X	ethylene oxide; oxirane	200-849-9	75-21-8	Press. Gas Flam. Gas 1 Carc. 1B Muta. 1B Acute Tox. 3 * Eye Irrit. 2 STOT SE 3 Skin Irrit. 2	H220 H350 H340 H331 H319 H335 H315	GHS02 GHS04 GHS06 GHS08 Dgr	H220 H350 H340 H331 H319 H335 H315		U

1 December 2010 · amended · CLP Annex VI section 3, Index No 603-023-00-X

Recorded in the version in force 1 December 2010, by Regulation (EC) No 790/2009, the act that change names. The change on its version page

Amended entries, Annex VI section 3, table 1
Identifiers	Version	Index No	International Chemical Identification	EC No	CAS No	Classification		Labelling			Notes
Identifiers	Version	Index No	International Chemical Identification	EC No	CAS No	Hazard Class and Category Code(s)	Hazard statement Code(s)	Pictogram, Signal Word Code(s)	Hazard statement Code(s)	Suppl. Hazard statement Code(s)
Index No 603-023-00-XCAS 75-21-8EC 200-849-9	Before	603-023-00-X	ethylene oxide; oxirane	200-849-9	75-21-8	Flam. Gas 1 ~~Press. Gas~~ Carc. 1B Muta. 1B Acute Tox. 3 * Eye Irrit. 2 STOT SE 3 Skin Irrit. 2	H220 H350 H340 H331 H319 H335 H315	GHS02 GHS04 GHS06 GHS08 Dgr	H220 H350 H340 H331 H319 H335 H315		U
Index No 603-023-00-XCAS 75-21-8EC 200-849-9	After	603-023-00-X	ethylene oxide; oxirane	200-849-9	75-21-8	Press. Gas Flam. Gas 1 Carc. 1B Muta. 1B Acute Tox. 3 * Eye Irrit. 2 STOT SE 3 Skin Irrit. 2	H220 H350 H340 H331 H319 H335 H315	GHS02 GHS04 GHS06 GHS08 Dgr	H220 H350 H340 H331 H319 H335 H315

1 December 2010 · amended · CLP Annex VI section 3, table 2, Index No 603-023-00-X

Recorded in the version in force 1 December 2010, by Regulation (EC) No 790/2009, the act that change names. The change on its version page

Amended entries, Annex VI section 3, table 2
Identifiers	Version	Index No	International Chemical Identification	EC No	CAS No	Classification	Labelling	Concentration Limits	Notes
Index No 603-023-00-XCAS 75-21-8EC 200-849-9	Before	603-023-00-X	ethylene oxide; oxirane	200-849-9	75-21-8	F+; R12 ⊗ Carc. Cat. 2; R45 Muta. Cat. 2; R46 T; R23 Xi; R36/37/38	F+; T R: ~~45-46-12-23-36/37/38~~ S: 53-45		E
Index No 603-023-00-XCAS 75-21-8EC 200-849-9	After	603-023-00-X	ethylene oxide; oxirane	200-849-9	75-21-8	F+; R12 R6 Carc. Cat. 2; R45 Muta. Cat. 2; R46 T; R23 Xi; R36/37/38	F+; T R: 45-46-6-12-23-36/37/38 S: 53-45		E

Sources

CLP: every version the record holds; rows read from EUR-Lex consolidated version 02008R1272-20270101, in force 1 January 2027 (external, EUR-Lex)
Cosmetics Regulation: every version the record holds; rows read from EUR-Lex consolidated version 02009R1223-20260518, in force 18 May 2026 (external, EUR-Lex)
PIC Regulation: every version the record holds; rows read from EUR-Lex consolidated version 02012R0649-20261001, in force 1 October 2026 (external, EUR-Lex)
Plant Protection Products Regulation: every version the record holds; rows read from EUR-Lex consolidated version 02009R1107-20260616, in force 16 June 2026 (external, EUR-Lex)
REACH: every version the record holds; rows read from EUR-Lex consolidated version 02006R1907-20260622, detected 11 September 2026 (external, EUR-Lex)

Watch this substance