CAS number

CAS 92-87-5 Benzidine

CAS 91-59-8 · CAS 92-67-1 · CAS 92-87-5 · CAS 92-93-3 · CAS 552-89-6 · CAS 36341-27-2 · CAS 68990-67-0 · EC 202-080-4 · EC 202-177-1 · EC 202-199-1 · EC 202-204-7 · EC 209-025-3 · EC 252-984-8 · EC 273-620-4 · Index No 612-042-00-2

Where CAS 92-87-5 appears: every table entry that prints it among its identifiers, in the newest version of each act this record holds, and every recorded change to those entries. Many entries name a group of substances and print no number, so absence here is not absence from the law. Not legal advice.

Where it appears now

CLP Annex VI section 3, Index No 612-042-00-2

No change to this entry since the first version the record holds, in force 1 December 2010. · Annex VI on this site

Annex VI section 3, table 1
Index No	Chemical name	EC No	CAS No	Classification		Labelling			Specific Conc. Limits, M-factors and ATEs	Notes
Index No	Chemical name	EC No	CAS No	Hazard Class and Category Code(s)	Hazard statement Code(s)	Pictogram, Signal Word Code(s)	Hazard statement Code(s)	Suppl. Hazard statement Code(s)	Specific Conc. Limits, M-factors and ATEs	Notes
612-042-00-2	benzidine; 1,1'-biphenyl-4,4'-diamine; 4,4'-diaminobiphenyl; biphenyl-4,4'-ylenediamine	202-199-1	92-87-5	Carc. 1A Acute Tox. 4 * Aquatic Acute 1 Aquatic Chronic 1	H350 H302 H400 H410	GHS08 GHS07 GHS09 Dgr	H350 H302 H410		Carc. 1A; H350: C ≥ 0,01 %

CLP Annex VI section 3, table 2, Index No 612-042-00-2

No change to this entry since the first version the record holds, in force 1 December 2010. · Annex VI on this site

Annex VI section 3, table 2
Index No	International Chemical Identification	EC No	CAS No	Classification	Labelling	Concentration Limits	Notes
612-042-00-2	benzidine; 1,1'-biphenyl-4,4'-diamine; 4,4'-diaminobiphenyl; biphenyl-4,4'-ylenediamine	202-199-1	92-87-5	Carc. Cat. 1; R45 Xn; R22 N; R50-53	T; N R: 45-22-50/53 S: 53-45-60-61	Carc. Cat. 1; R45: C ≥ 0,01 %	E

Cosmetics Regulation Annex II, Reference number 26

No change to this entry since the first version the record holds, in force 11 July 2013. · Annex II on this site

Annex II, table 1
Reference number	Substance identification
Reference number	Chemical name/INN	CAS number	EC number
a	b	c	d
26	Benzidine	92-87-5	202-199-1

PIC Regulation Annex I, the entry for Benzidine and its salts

Last changed in the version in force 1 July 2022, by Regulation (EU) 2022/643, the act that change names · Annex I on this site

Annex I, table 1
Chemical	CAS No	EC No	CN code	Subcategory	Use limitation	Countries for which no notification is required
Benzidine and its salts Benzidine derivatives	92-87-5 36341-27-2 and others	202-199-1 252-984-8 and others	ex29215990	i(1)-i(2)	sr-b
Benzidine and its salts Benzidine derivatives	92-87-5 36341-27-2 and others	202-199-1 252-984-8 and others	ex29215990	i(2)	b

PIC Regulation Annex I, table 2, the entry for Benzidine and its salts

Last changed in the version in force 1 July 2022, by Regulation (EU) 2022/643, the act that change names · Annex I on this site

Annex I, table 2
Chemical	CAS No	EC No	CN code	Category	Use limitation
Benzidine and its salts Benzidine derivatives	92-87-5 36341-27-2 and others	202-199-1 252-984-8 and others	ex29215990	i	sr

REACH Annex XVII, Entry 9

Last changed in the version in force 27 June 2009, by Regulation (EC) No 552/2009, the act that change names · Annex XVII on this site

Annex XVII, table 1
Column 1 Designation of the substance, of the group of substances or of the mixture	Column 2 Conditions of restriction
9. (a) Soap bark powder (Quillaja saponaria) and its derivatives containing saponines CAS No 68990-67-0 EC 273-620-4 (b) Powder of the roots of Helleborus viridis and Helleborus niger (c) Powder of the roots of Veratrum album and Veratrum nigrum (d) Benzidine and/or its derivatives CAS No 92-87-5 EC No 202-199-1 (e) o-Nitrobenzaldehyde CAS No 552-89-6 EC No 209-025-3 (f) Wood powder	1. Shall not be used, in jokes and hoaxes or in mixtures or articles intended to be used as such, for instance as a constituent of sneezing powder and stink bombs. 2. Jokes and hoaxes, or mixtures or articles intended to be used as such, not complying with paragraph 1 shall not be placed on the market. 3. However, paragraphs 1 and 2 shall not apply to stink bombs containing not more than 1,5 ml of liquid.

REACH Annex XVII, Entry 12

Last changed in the version in force 27 June 2009, by Regulation (EC) No 552/2009, the act that change names · Annex XVII on this site

Annex XVII, table 1
Column 1 Designation of the substance, of the group of substances or of the mixture	Column 2 Conditions of restriction
12. 2-Naphthylamine CAS No 91-59-8 EC No 202-080-4 and its salts 13. Benzidine CAS No 92-87-5 EC No 202-199-1 and its salts 14. 4-Nitrobiphenyl CAS No 92-93-3 Einecs EC No 202-204-7 15. 4-Aminobiphenyl xenylamine CAS No 92-67-1 Einecs EC No 202-177-1 and its salts	The following shall apply to entries 12 to 15: Shall not be placed on the market, or used, as substances or in mixtures in concentrations greater than 0,1 % by weight.

REACH Annex XVII appendix 1, Index No 612-042-00-2

No change to this entry since the first version the record holds, in force 12 October 2008. · Annex XVII on this site

Annex XVII appendix 1, table 1
Substances	Index No	EC No	CAS No	Notes
Benzidine; 4,4′-diaminobiphenyl; biphenyl-4,4′-ylenediamine	612-042-00-2	202-199-1	92-87-5	E

REACH Annex XVII appendix 8, No 2

No change to this entry since the first version the record holds, in force 12 October 2008. · Annex XVII on this site

Annex XVII appendix 8, table 1
	CAS No	Index No	EC No	Substances
2.	92-87-5	612-042-00-2	202-199-1	benzidine

REACH Annex XVII appendix 13, CAS No 92-87-5

Last changed in the version in force 4 January 2021, by Regulation (EU) 2020/2081 and 3 others, the acts that change names · Annex XVII on this site

Annex XVII appendix 13, table 1
Substance name	EC No	CAS No	Concentration limit (by weight)
Benzidine	202-199-1	92-87-5	0,0005 %

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Its history

1 July 2022 · amended · PIC Regulation Annex I, the entry for Benzidine and its salts

Recorded in the version in force 1 July 2022, by Regulation (EU) 2022/643, the act that change names. The change on its version page

Amended entries, Annex I, table 1
Identifiers	Version	Chemical	CAS No	EC No	CN code	Subcategory	Use limitation
Benzidine and its saltsCAS 36341-27-2CAS 92-87-5EC 202-199-1EC 252-984-8	Before	Benzidine and its salts Benzidine derivatives	~~92-87-5,~~ 36341-27-2 and others	~~202-199-1,~~ 252-984-8 and others	~~29215990~~	i(1)-i(2)	sr-b
	Before	Benzidine and its salts Benzidine derivatives	~~92-87-5,~~ 36341-27-2 and others	~~202-199-1,~~ 252-984-8 and others	~~29215990~~	i(2)	b
	After	Benzidine and its salts Benzidine derivatives	92-87-5 36341-27-2 and others	202-199-1 252-984-8 and others	ex29215990	i(1)-i(2)	sr-b
	After	Benzidine and its salts Benzidine derivatives	92-87-5 36341-27-2 and others	202-199-1 252-984-8 and others	ex29215990	i(2)	b

1 July 2022 · amended · PIC Regulation Annex I, table 2, the entry for Benzidine and its salts

Recorded in the version in force 1 July 2022, by Regulation (EU) 2022/643, the act that change names. The change on its version page

Amended entries, Annex I, table 2
Identifiers	Version	Chemical	CAS No	EC No	CN code	Category	Use limitation
Benzidine and its saltsCAS 36341-27-2CAS 92-87-5EC 202-199-1EC 252-984-8	Before	Benzidine and its salts	~~92-87-5,~~ 36341-27-2 and others	~~202-199-1,~~ 252-984-8 and others	~~29215990~~	i	sr
	After	Benzidine and its saltsBenzidine derivatives	92-87-5 36341-27-2 and others	202-199-1 252-984-8 and others	ex29215990	i	sr

4 January 2021 · added · REACH Annex XVII appendix 13, CAS No 92-87-5

Recorded in the version in force 4 January 2021, by Regulation (EU) 2020/2081 and 3 others, the acts that change names. The change on its version page

Added entries, Annex XVII appendix 13, table 1
Identifiers	Substance name	EC No	CAS No	Concentration limit (by weight)
CAS No 92-87-5CAS 92-87-5EC 202-199-1	Benzidine	202-199-1	92-87-5	0,0005 %

27 June 2009 · amended · REACH Annex XVII, Entry 9

Recorded in the version in force 27 June 2009, by Regulation (EC) No 552/2009, the act that change names. The change on its version page

Amended entries, Annex XVII, table 1
Identifiers	Version	Column 1 Designation of the substance, of the group of substances or of the mixture	Column 2 Conditions of restriction
Entry 9CAS 552-89-6CAS 68990-67-0CAS 92-87-5EC 202-199-1EC 209-025-3EC 273-620-4	Before	9. Soap bark powder (Quillaja saponaria) and its derivatives containing saponines Powder of the roots of Helleborus viridis and Helleborus niger Powder of the roots of Veratrum album and Veratrum nigrum Benzidine and/or its derivatives CAS No 92-87-5 ~~EINECS~~ No 202-199-1 o-Nitrobenzaldehyde CAS No 552-89-6 Wood powder	1. Shall not be ~~used~~ in jokes and hoaxes or in ~~objects~~ intended to be used as such, for instance as a constituent of sneezing powder and stink bombs. 2. ~~However,~~ paragraph 1 ~~does~~ not apply to stink bombs containing not more than 1,5 ml of liquid.
	After	9. (a) Soap bark powder (Quillaja saponaria) and its derivatives containing saponines CAS No 68990-67-0 EC 273-620-4 (b) Powder of the roots of Helleborus viridis and Helleborus niger (c) Powder of the roots of Veratrum album and Veratrum nigrum (d) Benzidine and/or its derivatives CAS No 92-87-5 EC No 202-199-1 (e) o-Nitrobenzaldehyde CAS No 552-89-6 EC No 209-025-3 (f) Wood powder	1. Shall not be used, in jokes and hoaxes or in mixtures or articles intended to be used as such, for instance as a constituent of sneezing powder and stink bombs. 2. Jokes and hoaxes, or mixtures or articles intended to be used as such, not complying with paragraph 1 shall not be placed on the market. 3. However, paragraphs 1 and 2 shall not apply to stink bombs containing not more than 1,5 ml of liquid.

27 June 2009 · amended · REACH Annex XVII, Entry 12

Recorded in the version in force 27 June 2009, by Regulation (EC) No 552/2009, the act that change names. The change on its version page

Amended entries, Annex XVII, table 1
Identifiers	Version	Column 1 Designation of the substance, of the group of substances or of the mixture	Column 2 Conditions of restriction
Entry 12CAS 91-59-8CAS 92-67-1CAS 92-87-5CAS 92-93-3EC 202-080-4EC 202-177-1EC 202-199-1EC 202-204-7	Before	12. 2-Naphthylamine CAS No 91-59-8 ~~EINECS~~ No 202-080-4 and its salts 13. Benzidine CAS No 92-87-5 ~~EINECS~~ No 202-199-1 and its salts 14. 4-Nitrobiphenyl CAS No 92-93-3 ~~EINECS~~ No 202-204-7 15. 4-Aminobiphenyl xenylamine CAS No 92-67-1 ~~EINECS~~ No 202-177-1 and its salts	1. Shall not be ~~used~~ in concentrations ~~equal to or~~ greater than 0,1 % by weight in substances and mixtures placed on the market. However, this provision shall not apply to waste containing one or more of these substances and covered by Directives 91/689/EEC and 2006/12/EC. 2. Such substances and mixtures shall not be sold to the general public. 3 Without prejudice to the application of other Community provisions on the classification, packaging and labelling of dangerous substances and mixtures, the packaging of such mixtures shall be legible and indelibly marked as follows: Restricted to professional users.
	After	12. 2-Naphthylamine CAS No 91-59-8 EC No 202-080-4 and its salts 13. Benzidine CAS No 92-87-5 EC No 202-199-1 and its salts 14. 4-Nitrobiphenyl CAS No 92-93-3 Einecs EC No 202-204-7 15. 4-Aminobiphenyl xenylamine CAS No 92-67-1 Einecs EC No 202-177-1 and its salts	The following shall apply to entries 12 to 15: Shall not be placed on the market, or used, as substances or in mixtures in concentrations greater than 0,1 % by weight.

20 January 2009 · amended · REACH Annex XVII, Entry 12

Recorded in the version in force 20 January 2009, by Regulation (EC) No 1272/2008, the act that change names. The change on its version page

Amended entries, Annex XVII, table 1
Identifiers	Version	Designation of the substance, of the groups of substances or of the mixture	Conditions of restriction
Entry 12CAS 91-59-8CAS 92-67-1CAS 92-87-5CAS 92-93-3EC 202-080-4EC 202-177-1EC 202-199-1EC 202-204-7	Before	12. 2-Naphthylamine CAS No 91-59-8 EINECS No 202-080-4 and its salts 13. Benzidine CAS No 92-87-5 EINECS No 202-199-1 and its salts 14. 4-Nitrobiphenyl CAS No 92-93-3 EINECS No 202-204-7 15. 4-Aminobiphenyl xenylamine CAS No 92-67-1 EINECS No 202-177-1 and its salts	1. Shall not be used in concentrations equal to or greater than 0,1 % by weight in substances and ~~preparations~~ placed on the market. However, this provision shall not apply to waste containing one or more of these substances and covered by Directives 91/689/EEC and 2006/12/EC. 2. Such substances and ~~preparations~~ shall not be sold to the general public. 3 Without prejudice to the application of other Community provisions on the classification, packaging and labelling of dangerous substances and ~~preparations,~~ the packaging of such ~~preparations~~ shall be legible and indelibly marked as follows: Restricted to professional users.
	After	12. 2-Naphthylamine CAS No 91-59-8 EINECS No 202-080-4 and its salts 13. Benzidine CAS No 92-87-5 EINECS No 202-199-1 and its salts 14. 4-Nitrobiphenyl CAS No 92-93-3 EINECS No 202-204-7 15. 4-Aminobiphenyl xenylamine CAS No 92-67-1 EINECS No 202-177-1 and its salts	1. Shall not be used in concentrations equal to or greater than 0,1 % by weight in substances and mixtures placed on the market. However, this provision shall not apply to waste containing one or more of these substances and covered by Directives 91/689/EEC and 2006/12/EC. 2. Such substances and mixtures shall not be sold to the general public. 3 Without prejudice to the application of other Community provisions on the classification, packaging and labelling of dangerous substances and mixtures, the packaging of such mixtures shall be legible and indelibly marked as follows: Restricted to professional users.

Sources

CLP: every version the record holds; rows read from EUR-Lex consolidated version 02008R1272-20270101, in force 1 January 2027 (external, EUR-Lex)
Cosmetics Regulation: every version the record holds; rows read from EUR-Lex consolidated version 02009R1223-20260518, in force 18 May 2026 (external, EUR-Lex)
PIC Regulation: every version the record holds; rows read from EUR-Lex consolidated version 02012R0649-20261001, in force 1 October 2026 (external, EUR-Lex)
REACH: every version the record holds; rows read from EUR-Lex consolidated version 02006R1907-20260622, detected 11 September 2026 (external, EUR-Lex)

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