CAS number
CAS 54-11-5 Nicotine
CAS 54-11-5 · EC 200-193-3 · Index No 614-001-00-4
Where CAS 54-11-5 appears: every table entry that prints it among its identifiers, in the newest version of each act this record holds, and every recorded change to those entries. Many entries name a group of substances and print no number, so absence here is not absence from the law. Not legal advice.
Where it appears now
CLP Annex VI section 3, Index No 614-001-00-4
Last changed in the version in force , by Regulation (EU) 2018/1480, the act that change names · Annex VI on this site
| Index No | Chemical name | EC No | CAS No | Classification | Labelling | Specific Conc. Limits, M-factors and ATEs | Notes | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Hazard Class and Category Code(s) | Hazard statement Code(s) | Pictogram, Signal Word Code(s) | Hazard statement Code(s) | Suppl. Hazard statement Code(s) | ||||||
| 614-001-00-4 | nicotine (ISO); 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine | 200-193-3 | 54-11-5 | Acute Tox. 2 Acute Tox. 2 Acute Tox. 2 Aquatic Chronic 2 | H330 H310 H300 H411 | GHS06 GHS09 Dgr | H330 H310 H300 H411 | inhalation: ATE = 0,19 mg/L (dusts or mists) dermal: ATE = 70 mg/kg bw oral: ATE = 5 mg/kg bw | ||
CLP Annex VI section 3, table 2, Index No 614-001-00-4
No change to this entry since the first version the record holds, in force 1 December 2010. · Annex VI on this site
| Index No | International Chemical Identification | EC No | CAS No | Classification | Labelling | Concentration Limits | Notes |
|---|---|---|---|---|---|---|---|
| 614-001-00-4 | nicotine (ISO); 3-(N-methyl-2-pyrrolidinyl)pyridine | 200-193-3 | 54-11-5 | T+; R27 T; R25 N; R51-53 | T+; N R: 25-27-51/53 S: (1/2-)36/37-45-61 |
Cosmetics Regulation Annex II, Reference number 246
No change to this entry since the first version the record holds, in force 11 July 2013. · Annex II on this site
| Reference number | Substance identification | ||
|---|---|---|---|
| Chemical name/INN | CAS number | EC number | |
| a | b | c | d |
| 246 | Nicotine and its salts | 54-11-5 | 200-193-3 |
PIC Regulation Annex I, the entry for Nicotine
Last changed in the version in force , by Regulation (EU) 2022/643, the act that change names · Annex I on this site
| Chemical | CAS No | EC No | CN code | Subcategory | Use limitation | Countries for which no notification is required |
|---|---|---|---|---|---|---|
| Nicotine | 54-11-5 | 200-193-3 | ex29397910 | p(1) | b |
PIC Regulation Annex I, table 2, the entry for Nicotine
Last changed in the version in force , by Regulation (EU) 2022/643, the act that change names · Annex I on this site
| Chemical | CAS No | EC No | CN code | Category | Use limitation |
|---|---|---|---|---|---|
| Nicotine | 54-11-5 | 200-193-3 | ex29397910 | p | b |
Look up a number
Type a CAS or EC number, with or without its hyphens, or an Index No into the search box at the top of the page: it reads 50000 as CAS 50-00-0. Every number is also listed by act on the substances page.
Its history
· amended · PIC Regulation Annex I, the entry for Nicotine
Recorded in the version in force , by Regulation (EU) 2022/643, the act that change names. The change on its version page
| Identifiers | Version | Chemical | CAS No | EC No | CN code | Subcategory | Use limitation | Countries for which no notification is required |
|---|---|---|---|---|---|---|---|---|
| NicotineCAS 54-11-5EC 200-193-3 | Before | Nicotine | 54-11-5 | 200-193-3 | p(1) | b | ||
| After | Nicotine | 54-11-5 | 200-193-3 | ex29397910 | p(1) | b |
· amended · PIC Regulation Annex I, table 2, the entry for Nicotine
Recorded in the version in force , by Regulation (EU) 2022/643, the act that change names. The change on its version page
| Identifiers | Version | Chemical | CAS No | EC No | CN code | Category | Use limitation |
|---|---|---|---|---|---|---|---|
| NicotineCAS 54-11-5EC 200-193-3 | Before | Nicotine | 54-11-5 | 200-193-3 | p | b | |
| After | Nicotine | 54-11-5 | 200-193-3 | ex29397910 | p | b |
· amended · CLP Annex VI section 3, Index No 614-001-00-4
Recorded in the version in force , by Regulation (EU) 2018/1480, the act that change names. The change on its version page
| Identifiers | Version | Index No | Chemical name | EC No | CAS No | Classification | Labelling | Specific Conc. Limits, M-factors and ATEs | Notes | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hazard Class and Category Code(s) | Hazard statement Code(s) | Pictogram, Signal Word Code(s) | Hazard statement Code(s) | Suppl. Hazard statement Code(s) | ||||||||
| Index No 614-001-00-4CAS 54-11-5EC 200-193-3 | Before | 614-001-00-4 | nicotine (ISO); 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine | 200-193-3 | 54-11-5 | Acute Tox. 2 Acute Tox. 2 Acute Tox. 2 Aquatic Chronic 2 | H330 H310 H300 H411 | GHS06 GHS09 Dgr | H330 H310 H300 H411 | inhalation:
ATE = | ||
| After | 614-001-00-4 | nicotine (ISO); 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine | 200-193-3 | 54-11-5 | Acute Tox. 2 Acute Tox. 2 Acute Tox. 2 Aquatic Chronic 2 | H330 H310 H300 H411 | GHS06 GHS09 Dgr | H330 H310 H300 H411 | inhalation: ATE = 0,19 mg/L (dusts or mists) dermal: ATE = 70 mg/kg bw oral: ATE = 5 mg/kgbw | |||
· amended · CLP Annex VI section 3, Index No 614-001-00-4
Recorded in the version in force , by Regulation (EU) 2017/776, the act that change names. The change on its version page
| Identifiers | Version | Index No | International Chemical Identification | EC No | CAS No | Classification | Labelling | Specific Conc. Limits, M-factors and ATE | Notes | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hazard Class and Category Code(s) | Hazard statement Code(s) | Pictogram, Signal Word Code(s) | Hazard statement Code(s) | Suppl. Hazard statement Code(s) | ||||||||
| Index No 614-001-00-4CAS 54-11-5EC 200-193-3 | Before | 614-001-00-4 | nicotine (ISO);
| 200-193-3 | 54-11-5 | Acute Tox. | H310
| GHS06 GHS09 Dgr | H310
| |||
| After | 614-001-00-4 | nicotine (ISO); 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine | 200-193-3 | 54-11-5 | Acute Tox. 2 Acute Tox. 2 Acute Tox. 2 Aquatic Chronic 2 | H330 H310 H300 H411 | GHS06 GHS09 Dgr | H330 H310 H300 H411 | inhalation: ATE = 0.19 mg/L (dusts or mists) dermal: ATE = 70 mg/kg oral: ATE = 5 mg/kg | |||
Sources
- CLP: every version the record holds; rows read from EUR-Lex consolidated version 02008R1272-20270101, in force 1 January 2027 (external, EUR-Lex)
- Cosmetics Regulation: every version the record holds; rows read from EUR-Lex consolidated version 02009R1223-20260518, in force 18 May 2026 (external, EUR-Lex)
- PIC Regulation: every version the record holds; rows read from EUR-Lex consolidated version 02012R0649-20261001, in force 1 October 2026 (external, EUR-Lex)