EC number
EC 219-799-4 4,4'-methylenediphenyl diisocyanate
CAS 101-68-8 · CAS 2536-05-2 · CAS 5873-54-1 · CAS 26447-40-5 · EC 202-966-0 · EC 219-799-4 · EC 227-534-9 · EC 247-714-0 · Index No 615-005-00-9
Where EC 219-799-4 appears: every table entry that prints it among its identifiers, in the newest version of each act this record holds, and every recorded change to those entries. Many entries name a group of substances and print no number, so absence here is not absence from the law. Not legal advice.
Where it appears now
CLP Annex VI section 3, Index No 615-005-00-9
Last changed in the version in force , by Regulation (EU) No 286/2011, the act that change names · Annex VI on this site
| Index No | Chemical name | EC No | CAS No | Classification | Labelling | Specific Conc. Limits, M-factors and ATEs | Notes | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Hazard Class and Category Code(s) | Hazard statement Code(s) | Pictogram, Signal Word Code(s) | Hazard statement Code(s) | Suppl. Hazard statement Code(s) | ||||||
| 615-005-00-9 | 4,4'-methylenediphenyl diisocyanate; diphenylmethane-4,4'-diisocyanate; [1] 2,2'-methylenediphenyl diisocyanate; diphenylmethane-2,2'-diisocyanate; [2] o-(p-isocyanatobenzyl)phenyl isocyanate; diphenylmethane-2,4'-diisocyanate; [3] methylenediphenyl diisocyanate [4] | 202-966-0 [1] 219-799-4 [2] 227-534-9 [3] 247-714-0 [4] | 101-68-8 [1] 2536-05-2 [2] 5873-54-1 [3] 26447-40-5 [4] | Carc. 2 Acute Tox. 4 * STOT RE 2 * Eye Irrit. 2 STOT SE 3 Skin Irrit. 2 Resp. Sens. 1 Skin Sens. 1 | H351 H332 H373** H319 H335 H315 H334 H317 | GHS08 GHS07 Dgr | H351 H332 H373** H319 H335 H315 H334 H317 | Eye Irrit. 2; H319: C ≥ 5 % Skin Irrit. 2; H315: C ≥ 5 % Resp. Sens. 1; H334: C ≥ 0,1 % STOT SE 3; H335: C ≥ 5 % | C2 | |
CLP Annex VI section 3, table 2, Index No 615-005-00-9
Last changed in the version in force , by Regulation (EU) No 286/2011, the act that change names · Annex VI on this site
| Index No | International Chemical Identification | EC No | CAS No | Classification | Labelling | Concentration Limits | Notes |
|---|---|---|---|---|---|---|---|
| 615-005-00-9 | 4,4'-methylenediphenyl diisocyanate; diphenylmethane-4,4'-diisocyanate; [1] 2,2'-methylenediphenyl diisocyanate; diphenylmethane-2,2'-diisocyanate; [2] o-(p-isocyanatobenzyl)phenyl isocyanate; diphenylmethane-2,4'-diisocyanate; [3] methylenediphenyl diisocyanate [4] | 202-966-0 [1] 219-799-4 [2] 227-534-9 [3] 247-714-0 [4] | 101-68-8 [1] 2536-05-2 [2] 5873-54-1 [3] 26447-40-5 [4] | Carc. Cat. 3; R40 Xn; R20-48/20 Xi; R36/37/38 R42/43 | Xn R: 20-36/37/38-40-42/43-48/20 S: (1/2-)23-36/37-45 | Xi; R36/37/38: C ≥ 5 % R42: C ≥ 0,1 % | C2 |
Cosmetics Regulation Annex II, Reference number 1533
Last changed in the version in force , by Regulation (EU) 2019/831 and 5 others, the acts that change names · Annex II on this site
| Reference number | Substance identification | ||
|---|---|---|---|
| Chemical name/INN | CAS number | EC number | |
| a | b | c | d |
| 1533 | 4,4′-Methylenediphenyl diisocyanate; diphenylmethane-4,4′-diisocyanate [1] | 101-68-8 [1] | 202-966-0 [1] |
| 2,2′-Methylenediphenyl diisocyanate; diphenylmethane-2,2′-diisocyanate [2] | 2536-05-2 [2] | 219-799-4 [2] | |
| o-(p-Isocyanatobenzyl)phenyl isocyanate; diphenylmethane-2,4′-diisocyanate [3] | 5873-54-1 [3] | 227-534-9 [3] | |
| Methylenediphenyl diisocyanate [4] | 26447-40-5 [4] | 247-714-0 [4] | |
REACH Annex XVII, Entry 56
Last changed in the version in force , by Regulation (EU) No 126/2013, the act that change names · Annex XVII on this site
| Column 1 Designation of the substance, of the group of substances or of the mixture | Column 2 Conditions of restriction |
|---|---|
| 56. Methylenediphenyl diisocyanate (MDI) CAS No 26447-40-5 EC No 247-714-0 including the following specific isomers: (a) 4,4’-Methylenediphenyl diisocyanate: CAS No 101-68-8 EC No 202-966-0; (b) 2,4’-Methylenediphenyl diisocyanate: CAS No 5873-54-1 EC No 227-534-9; (c) 2,2’-Methylenediphenyl diisocyanate: CAS No 2536-05-2 EC No 219-799-4 | 1. Shall not be placed on the market after 27 December 2010, as a constituent of mixtures in concentrations equal to or greater than 0,1 % by weight of MDI for supply to the general public, unless suppliers shall ensure before the placing on the market that the packaging: (a) contains protective gloves which comply with the requirements of Council Directive 89/686/EEC ; (b) is marked visibly, legibly and indelibly as follows, and without prejudice to other Community legislation concerning the classification, packaging and labelling of substances and mixtures: — Persons already sensitised to diisocyanates may develop allergic reactions when using this product. — Persons suffering from asthma, eczema or skin problems should avoid contact, including dermal contact, with this product. — This product should not be used under conditions of poor ventilation unless a protective mask with an appropriate gas filter (i.e. type A1 according to standard EN 14387) is used. 2. By way of derogation, paragraph 1(a) shall not apply to hot melt adhesives. |
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Its history
· added · Cosmetics Regulation Annex II, Reference number 1533
Recorded in the version in force , by Regulation (EU) 2019/831 and 5 others, the acts that change names. The change on its version page
| Identifiers | Reference number | Substance identification | ||
|---|---|---|---|---|
| Chemical name/INN | CAS number | EC number | ||
| a | b | c | d | |
| Reference number 1533CAS 101-68-8CAS 2536-05-2CAS 26447-40-5CAS 5873-54-1EC 202-966-0EC 219-799-4EC 227-534-9EC 247-714-0 | 1533 | 4,4′-Methylenediphenyl diisocyanate; diphenylmethane-4,4′-diisocyanate [1] | 101-68-8 [1] | 202-966-0 [1] |
| 2,2′-Methylenediphenyl diisocyanate; diphenylmethane-2,2′-diisocyanate [2] | 2536-05-2 [2] | 219-799-4 [2] | ||
| o-(p-Isocyanatobenzyl)phenyl isocyanate; diphenylmethane-2,4′-diisocyanate [3] | 5873-54-1 [3] | 227-534-9 [3] | ||
| Methylenediphenyl diisocyanate [4] | 26447-40-5 [4] | 247-714-0 [4] | ||
· amended · REACH Annex XVII, Entry 56
Recorded in the version in force , by Regulation (EU) No 126/2013, the act that change names. The change on its version page
| Identifiers | Version | Column 1 Designation of the substance, of the group of substances or of the mixture | Column 2 Conditions of restriction |
|---|---|---|---|
| Entry 56CAS 101-68-8CAS 2536-05-2CAS 26447-40-5CAS 5873-54-1EC 202-966-0EC 219-799-4EC 227-534-9EC 247-714-0 | Before | 56. Methylenediphenyl diisocyanate (MDI) CAS No 26447-40-5 EC No 247-714-0 | 1. Shall not be placed on the market after 27 December 2010, as a constituent of mixtures in concentrations equal to or greater than 0,1 % by weight of MDI for supply to the general public, unless suppliers shall ensure before the placing on the market that the packaging: (a) contains protective gloves which comply with the requirements of Council Directive 89/686/EEC ; (b) is marked visibly, legibly and indelibly as follows, and without prejudice to other Community legislation concerning the classification, packaging and labelling of substances and mixtures: — Persons already sensitised to diisocyanates may develop allergic reactions when using this product. — Persons suffering from asthma, eczema or skin problems should avoid contact, including dermal contact, with this product. — This product should not be used under conditions of poor ventilation unless a protective mask with an appropriate gas filter (i.e. type A1 according to standard EN 14387) is used. 2. By way of derogation, paragraph 1(a) shall not apply to hot melt adhesives. |
| After | 56. Methylenediphenyl diisocyanate (MDI) CAS No 26447-40-5 EC No 247-714-0including the following specific isomers: (a) 4,4’-Methylenediphenyl diisocyanate: CAS No 101-68-8 EC No 202-966-0; (b) 2,4’-Methylenediphenyl diisocyanate: CAS No 5873-54-1 EC No 227-534-9; (c) 2,2’-Methylenediphenyl diisocyanate: CAS No 2536-05-2 EC No 219-799-4 | 1. Shall not be placed on the market after 27 December 2010, as a constituent of mixtures in concentrations equal to or greater than 0,1 % by weight of MDI for supply to the general public, unless suppliers shall ensure before the placing on the market that the packaging: (a) contains protective gloves which comply with the requirements of Council Directive 89/686/EEC ; (b) is marked visibly, legibly and indelibly as follows, and without prejudice to other Community legislation concerning the classification, packaging and labelling of substances and mixtures: — Persons already sensitised to diisocyanates may develop allergic reactions when using this product. — Persons suffering from asthma, eczema or skin problems should avoid contact, including dermal contact, with this product. — This product should not be used under conditions of poor ventilation unless a protective mask with an appropriate gas filter (i.e. type A1 according to standard EN 14387) is used. 2. By way of derogation, paragraph 1(a) shall not apply to hot melt adhesives. |
· amended · CLP Annex VI section 3, Index No 615-005-00-9
Recorded in the version in force , by Regulation (EU) No 286/2011, the act that change names. Only spacing, dash forms or accents differ. The change on its version page
| Identifiers | Version | Index No | International Chemical Identification | EC No | CAS No | Classification | Labelling | Specific Conc. Limits, M-factors | Notes | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hazard Class and Category Code(s) | Hazard statement Code(s) | Pictogram, Signal Word Code(s) | Hazard statement Code(s) | Suppl. Hazard statement Code(s) | ||||||||
| Index No 615-005-00-9CAS 101-68-8CAS 2536-05-2CAS 26447-40-5CAS 5873-54-1EC 202-966-0EC 219-799-4EC 227-534-9EC 247-714-0 | Before | 615-005-00-9 | 4,4'-methylenediphenyl diisocyanate; diphenylmethane-4,4'-diisocyanate; [1] 2,2'-methylenediphenyl diisocyanate; diphenylmethane-2,2'-diisocyanate; [2] o-(p-isocyanatobenzyl)phenyl isocyanate; diphenylmethane-2,4'-diisocyanate; [3] methylenediphenyl diisocyanate [4] | 202-966-0 [1] 219-799-4 [2] 227-534-9 [3] 247-714-0 [4] | 101-68-8 [1] 2536-05-2 [2] 5873-54-1 [3] 26447-40-5 [4] | Carc. 2 Acute Tox. 4 * STOT RE 2 * Eye Irrit. 2 STOT SE 3 Skin Irrit. 2 Resp. Sens. 1 Skin Sens. 1 | H351 H332 H373** H319 H335 H315 H334 H317 | GHS08 GHS07 Dgr | H351 H332 H373** H319 H335 H315 H334 H317 | Eye Irrit. 2; H319: C ≥ 5 % Skin Irrit. 2; H315: C ≥ 5 % Resp. Sens. 1; H334: C ≥ 0,1 % STOT SE 3; H335: C ≥ 5 % | ||
| After | 615-005-00-9 | 4,4'-methylenediphenyl diisocyanate; diphenylmethane-4,4'-diisocyanate; [1] 2,2'-methylenediphenyl diisocyanate; diphenylmethane-2,2'-diisocyanate; [2] o-(p-isocyanatobenzyl)phenyl isocyanate; diphenylmethane-2,4'-diisocyanate; [3] methylenediphenyl diisocyanate [4] | 202-966-0 [1] 219-799-4 [2] 227-534-9 [3] 247-714-0 [4] | 101-68-8 [1] 2536-05-2 [2] 5873-54-1 [3] 26447-40-5 [4] | Carc. 2 Acute Tox. 4 * STOT RE 2 * Eye Irrit. 2 STOT SE 3 Skin Irrit. 2 Resp. Sens. 1 Skin Sens. 1 | H351 H332 H373** H319 H335 H315 H334 H317 | GHS08 GHS07 Dgr | H351 H332 H373** H319 H335 H315 H334 H317 | Eye Irrit. 2; H319: C ≥ 5 % Skin Irrit. 2; H315: C ≥ 5 % Resp. Sens. 1; H334: C ≥ 0,1 % STOT SE 3; H335: C ≥ 5 % | C2 | ||
· amended · CLP Annex VI section 3, table 2, Index No 615-005-00-9
Recorded in the version in force , by Regulation (EU) No 286/2011, the act that change names. Only spacing, dash forms or accents differ. The change on its version page
| Identifiers | Version | Index No | International Chemical Identification | EC No | CAS No | Classification | Labelling | Concentration Limits | Notes |
|---|---|---|---|---|---|---|---|---|---|
| Index No 615-005-00-9CAS 101-68-8CAS 2536-05-2CAS 26447-40-5CAS 5873-54-1EC 202-966-0EC 219-799-4EC 227-534-9EC 247-714-0 | Before | 615-005-00-9 | 4,4'-methylenediphenyl diisocyanate; diphenylmethane-4,4'-diisocyanate; [1] 2,2'-methylenediphenyl diisocyanate; diphenylmethane-2,2'-diisocyanate; [2] o-(p-isocyanatobenzyl)phenyl isocyanate; diphenylmethane-2,4'-diisocyanate; [3] methylenediphenyl diisocyanate [4] | 202-966-0 [1] 219-799-4 [2] 227-534-9 [3] 247-714-0 [4] | 101-68-8 [1] 2536-05-2 [2] 5873-54-1 [3] 26447-40-5 [4] | Carc. Cat. 3; R40 Xn; R20-48/20 Xi; R36/37/38 R42/43 | Xn R: 20-36/37/38-40-42/43-48/20 S: (1/2-)23-36/37-45 | Xi; R36/37/38: C ≥ 5 % R42: C ≥ 0,1 % | |
| After | 615-005-00-9 | 4,4'-methylenediphenyl diisocyanate; diphenylmethane-4,4'-diisocyanate; [1] 2,2'-methylenediphenyl diisocyanate; diphenylmethane-2,2'-diisocyanate; [2] o-(p-isocyanatobenzyl)phenyl isocyanate; diphenylmethane-2,4'-diisocyanate; [3] methylenediphenyl diisocyanate [4] | 202-966-0 [1] 219-799-4 [2] 227-534-9 [3] 247-714-0 [4] | 101-68-8 [1] 2536-05-2 [2] 5873-54-1 [3] 26447-40-5 [4] | Carc. Cat. 3; R40 Xn; R20-48/20 Xi; R36/37/38 R42/43 | Xn R: 20-36/37/38-40-42/43-48/20 S: (1/2-)23-36/37-45 | Xi; R36/37/38: C ≥ 5 % R42: C ≥ 0,1 % | C2 |
· amended · CLP Annex VI section 3, Index No 615-005-00-9
Recorded in the version in force , by Regulation (EC) No 790/2009, the act that change names. The change on its version page
| Identifiers | Version | Index No | International Chemical Identification | EC No | CAS No | Classification | Labelling | Specific Conc. Limits, M-factors | Notes | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hazard Class and Category Code(s) | Hazard statement Code(s) | Pictogram, Signal Word Code(s) | Hazard statement Code(s) | Suppl. Hazard statement Code(s) | ||||||||
| Index No 615-005-00-9CAS 101-68-8CAS 2536-05-2CAS 26447-40-5CAS 5873-54-1EC 202-966-0EC 219-799-4EC 227-534-9EC 247-714-0 | Before | 615-005-00-9 | 4,4'-methylenediphenyl diisocyanate; diphenylmethane-4,4'-diisocyanate; [1] 2,2'-methylenediphenyl diisocyanate; diphenylmethane-2,2'-diisocyanate; [2] o-(p-isocyanatobenzyl)phenyl isocyanate; diphenylmethane-2,4'-diisocyanate; [3] methylenediphenyl diisocyanate [4] | 202-966-0 [1] 219-799-4 [2] 227-534-9 [3] 247-714-0 [4] | 101-68-8 [1] 2536-05-2 [2] 5873-54-1 [3] 26447-40-5 [4] | Acute Tox. 4 * Eye Irrit. 2 STOT SE 3 Skin Irrit. 2 Resp. Sens. 1 Skin Sens. 1 | H332 H319 H335 H315 H334 H317 | GHS08 GHS07 Dgr | H332 H319 H335 H315 H334 H317 | Eye | C 2 | |
| After | 615-005-00-9 | 4,4'-methylenediphenyl diisocyanate; diphenylmethane-4,4'-diisocyanate; [1] 2,2'-methylenediphenyl diisocyanate; diphenylmethane-2,2'-diisocyanate; [2] o-(p-isocyanatobenzyl)phenyl isocyanate; diphenylmethane-2,4'-diisocyanate; [3] methylenediphenyl diisocyanate [4] | 202-966-0 [1] 219-799-4 [2] 227-534-9 [3] 247-714-0 [4] | 101-68-8 [1] 2536-05-2 [2] 5873-54-1 [3] 26447-40-5 [4] | Carc. 2 Acute Tox. 4 * STOT RE 2 * Eye Irrit. 2 STOT SE 3 Skin Irrit. 2 Resp. Sens. 1 Skin Sens. 1 | H351 H332 H373** H319 H335 H315 H334 H317 | GHS08 GHS07 Dgr | H351 H332 H373** H319 H335 H315 H334 H317 | Eye Irrit. 2; H319: C ≥ 5 % Skin Irrit. 2; H315: C ≥ 5 % Resp. Sens. 1; H334: C ≥ 0,1 %STOT SE 3; H335: C ≥ 5 % | C 2 | ||
· amended · CLP Annex VI section 3, table 2, Index No 615-005-00-9
Recorded in the version in force , by Regulation (EC) No 790/2009, the act that change names. The change on its version page
| Identifiers | Version | Index No | International Chemical Identification | EC No | CAS No | Classification | Labelling | Concentration Limits | Notes |
|---|---|---|---|---|---|---|---|---|---|
| Index No 615-005-00-9CAS 101-68-8CAS 2536-05-2CAS 26447-40-5CAS 5873-54-1EC 202-966-0EC 219-799-4EC 227-534-9EC 247-714-0 | Before | 615-005-00-9 | 4,4'-methylenediphenyl diisocyanate; diphenylmethane-4,4'-diisocyanate; [1] 2,2'-methylenediphenyl diisocyanate; diphenylmethane-2,2'-diisocyanate; [2] o-(p-isocyanatobenzyl)phenyl isocyanate; diphenylmethane-2,4'-diisocyanate; [3] methylenediphenyl diisocyanate [4] | 202-966-0 [1] 219-799-4 [2] 227-534-9 [3] 247-714-0 [4] | 101-68-8 [1] 2536-05-2 [2] 5873-54-1 [3] 26447-40-5 [4] | Xn; | Xn
R: | Xi; R36/37/38: C ≥ 5 % R42: C ≥ 0,1 % | C 2 |
| After | 615-005-00-9 | 4,4'-methylenediphenyl diisocyanate; diphenylmethane-4,4'-diisocyanate; [1] 2,2'-methylenediphenyl diisocyanate; diphenylmethane-2,2'-diisocyanate; [2] o-(p-isocyanatobenzyl)phenyl isocyanate; diphenylmethane-2,4'-diisocyanate; [3] methylenediphenyl diisocyanate [4] | 202-966-0 [1] 219-799-4 [2] 227-534-9 [3] 247-714-0 [4] | 101-68-8 [1] 2536-05-2 [2] 5873-54-1 [3] 26447-40-5 [4] | Carc. Cat. 3; R40 Xn; R20-48/20 Xi; R36/37/38 R42/43 | Xn R: 20-36/37/38-40-42/43-48/20 S: (1/2-)23-36/37-45 | Xi; R36/37/38: C ≥ 5 % R42: C ≥ 0,1 % | C 2 |
Sources
- CLP: every version the record holds; rows read from EUR-Lex consolidated version 02008R1272-20270101, in force 1 January 2027 (external, EUR-Lex)
- Cosmetics Regulation: every version the record holds; rows read from EUR-Lex consolidated version 02009R1223-20260518, in force 18 May 2026 (external, EUR-Lex)
- REACH: every version the record holds; rows read from EUR-Lex consolidated version 02006R1907-20260622, detected 11 September 2026 (external, EUR-Lex)